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ピラジン・キノキサリン化合物の開発・製造 ~ 医薬品原料・電子材料への応用 ~

 当社では医薬品原料・電子材料への応用が期待されるピラジン・キノキサリン化合物の開発・受託製造を行っております。

考えられる用途:

  • エボラ出血熱治療薬で注目されるピラジン骨格
  • 不斉合成原料
  • 抗インフルエンザ薬:アビガン(一般名 ファビピラビル / Favipiravir) 等
  • 抗結核薬
  • 高脂血症治療薬
  • 色素増感太陽電池素材
  • 有機 EL 素子
  • 有機半導体
  • 電子感光体

  新規化合物にもラボスケールから対応させていただきます。

製品例の紹介(主な製造先:インド)

CAS No.品名構造式
1076198-72-52-(1-Acetoxyethyl)-3-ethyl-5-methylpyrazine
160252-31-3 5-Acetyl-2-chloropyrazine
21943-12-4 2-Amino-3-bromopyrazine
59489-71-3 2-Amino-5-bromopyrazine
887352-34-3 2-Amino-3-bromopyrazine-5-carboxylic acid
486424-37-7 2-Amino-5-bromopyrazine-3-carboxylic acid
6966-01-4 2-Amino-5-bromopyrazine-3-carboxylic acid methyl ester
6663-73-6,
6863-73-6
2-Amino-3-chloropyrazine
33332-29-5 2-Amino-5-chloropyrazine
33332-28-4 2-Amino-6-chloropyrazine
43029-19-2 2-Amino-3-hydroxypyrazine
771581-15-8 2-Aminomethyl-3-chloropyrazine
5049-61-6 2-Aminopyrazine
5424-01-1 3-Amino-2-pyrazinecarboxylic acid
40155-43-9 5-Amino-2-pyrazinecarboxylic acid
61442-38-4 6-Amino-2-pyrazinecarboxylic acid
40155-43-9 5-Aminopyrazine-2-carboxylic acid
13924-94-2 2-Aminopyrazine-5-carboxylic acid methyl ester
16298-03-6 3-Amino-2-pyrazinecarboxylic acid methyl ester
1076198-91-8 1-Benzyl 4-[6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl]piperazine-1,4-dicarboxylate
96681-85-5 3,6-Bis(2-hydroxyethyl)-2-pyrazinepropanoic acid
875781-43-4 2-Bromo-5H-pyrrolo[3,2-b]pyrazine
259793-88-9 6-Bromo-3-hydroxypyrazine-2-carboxamide
914452-71-4 2-Bromo-6-methylpyrazine
1416740-16-3 2-Bromo-7-nitro-5H-pyrrolo[3,2-b]pyrazine
59489-71-3 5-Bromopyrazin-2-amine
56423-63-3 2-Bromopyrazine
89123-58-0 5-Bromopyrazine-2,3-diamine
132426-19-8 2-Bromo-1-(2-pyrazinyl) ethanone
173256-61-6 2-Chloro-6-(2'-deoxy-b-D-ribofuranosyl)-3,5-diaminopyrazine
33332-25-1 5-Chloro-2-methoxycarbonyl pyrazine
40155-28-0 2-Chloro-3-methoxy pyrazine
1122549-47-6 3-(Chloromethyl)-N-(5-chloro-2-pyridinyl)-2-pyrazinecarboxamide
508169-18-4 7-Chloromethyloxy-carbonyloxy-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
36070-80-1 5-Chloropyrazine-2-carboxylic acid
23688-89-3 6-Chloropyrazine-2-carboxylic acid
27825-21-4 3-Chloro-2-pyrazinecarboxylic acid methyl ester
19847-12-2 2-Cyanopyrazine
402958-96-7 (2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valine
2015-16-9 Des(5-methylpyrazinecarbonyl) glipizide
1458-01-1 3,5-Diamino-6-chloropyrazine-2-carboxylic acid methyl ester
944709-42-6 6,8-Dibromo-[1,2,4]triazolo[1,5-a]pyrazine
957230-70-5 2,5-Dibromo-3-aminopyrazine
1082843-70-6 3,5-Dibromo-2-chloropyrazine
1198475-31-8 6,8-Dibromo-2-methyl-[1,2,4]triazolo[1,5-a]pyrazine
N/A 2,5-Dibromo-3-methylcarboxylatepyrazine
957230-70-5 3,6-Dibromopyrazin-2-amine
24241-18-7 3,5-Dibromopyrazin-2-amine
23229-26-7 2,5-Dibromopyrazine
23229-25-6 2,6-Dibromopyrazine
N/A 2,5-Dibromopyrazine-3-carboxylic acid
4858-85-9 2,3-Dichloropyrazine
4774-14-5 2,6-Dichloropyrazine
313339-92-3 3,5-Dichloropyrazine-2-carbonitrile
312736-49-5 3,5-Dichloropyrazine-2-carboxamide
52197-23-6 2,3-Dicyano-5,6-diphenylpyrazine
134870-62-5 (S)-3,6-Diethoxy-2,5-dihydro-2-isopropylpyrazine
1076200-01-5 2,3-Diethyl-5-methylpyrazine-N4-oxide
1076200-00-4 2,3-Diethyl-5-methylpyrazine-N1-oxide
312905-15-0 1,1-Difluorocyclopropane-1-dibenzosuberyl pyrazinium bromide
1174321-06-2 5-Difluoromethylpyrazine-2-carboxylic acid
356783-29-4 3,6-Difluoropyrazine-2-carboxamide
110117-71-0 (R)-2, 5-Dihydro-3,6-diethoxy-2-isopropylpyrazine
656241-17-7 (2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine
109838-85-9 (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
78342-42-4 (S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
1093418-77-9 2,5-Diiodopyrazine
13925-07-0 3,5-Dimethyl-2-ethylpyrazine
108-50-9 2,6-Dimethyl pyrazine
52197-22-5 2,3-Diphenyl-5,8-diaminopyrazino[2,3-d]pyridazine
79790-37-7 Dipyrazino[2,3-f:2',3'-h]quinoxaline
157615-33-3 2-Ethenyl-3,5-dimethylpyrazine
181589-32-2 2-Ethenyl-3-ethyl-5-methylpyrazine
N/A Ethyl-1-[2-(2-oxo-2-pyrazin-2-ylethylidene)tetrahydropyrimidin-1-yl]ethanoate
54013-06-8 Ethyl 5-aminopyrazine-2-carboxylate
27043-05-6,
55031-15-7
2-Ethyl-3,5-dimethylpyrazine
86917-74-0 3-Ethyl-2,5-pyrazinediethanol
N/A Hexyl-3-[5-(2-hexyloxycarbonylethyl)pyrazin-2-yl]propionate
N/A 2-Hydroxy-3,3-dimethyl-2,3-dihydropyrazine>
-1,4-dioxide
34604-60-9 5-Hydroxypyrazine-2-carboxylic acid
77112-53-9 Imidazo[1,2-a]pyrazine-2-carboxylic acid
38521-06-1 2-Mercaptopyrazine
40155-42-8 5-Methoxypyrazine-2-carboxylic acid
77479-01-7 Methyl-3-[5-(2-methoxycarbonylethyl)pyrazin-2-yl]propionate
1076198-49-6 Methyl 2-amino-3-bromopyrazine-5-carboxylate
5521-55-1 5-Methyl-2-pyrazinecarboxylic acid
51037-30-0 5-Methylpyrazine-2-carboxylic acid 4-oxide
54709-94-3 5-Methylpyrazinone
1122549-43-2 N-(5-Chloro-2-pyridinyl)-3-(hydroxymethyl)-2-pyrazinecarboxamide
13554-93-3 N-Des(5-methylpyrazinecarbonyl)-N-ethylcarboxyl glipizide
114457-94-2 N-Pyrazinylcarbonyl-L-phenylalanine
73058-37-4 N-Pyrazinylcarbonyl-L-phenylalanine methyl ester
24177-07-9 (2R,5S,10aS,10bS)-Octahydro-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxo-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine-2-carboxylic acid
1159825-34-9 Octahydro-2H-pyrazino[1,2-a]pyrazine-2-carboxylic acid tert-butyl ester
6303-75-9 Pentylpyrazine
205393-22-2 (1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate
98-96-4 Pyrazinamide
768-05-8 Pyrazine-2-carbohydrazide
98-97-5 Pyrazine-2-carboxylic acid
874-54-4 2-Pyrazinecarboxylic acid 4-oxide
89-01-0 2,3-Pyrazine dicarboxylic acid
4744-51-8 2,5-Pyrazinediethanol
2423-84-9 Pyrazine 1,4-dioxide
24168-70-5 2-sec-Butyl-3-methoxypyrazine
51440-69-8 5-(tert-Butyl)pyrazine-2,3-dicarbonitrile
230615-70-0 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine
88571-73-7 2,2,5,5-Tetramethyl-2,5-dihydropyrazine-1,4-dioxide
1124-11-4 2,3,5,6-Tetra-methyl-pyrazine

開発製品例の紹介

A. Alkylpyrazine and Alkylpyrazine N-oxides

1)2,5-dialkylpyrazine

2)2,5-alkylpyrazine mono-N-oxides
2,5-alkylpyrazine mono-N-oxides

3)2,5-alkylpyrazine di-N-oxides
2,5-alkylpyrazine di-N-oxides

B. Arylpyrazines

1) monoarylpyrazines

2) 2,3-diarylpyrazines

3) 2,3-diarylpyrazine N-oxides

4) 2,5-diarylpyrazines

5) 2,6-diarylpyrazines

C. Condensation pyrazines

C. Condensation pyrazines

その他の誘導体への対応

 当社では、ピラジン(Pyrazine)及びピラジン N-オキシド(Pyrazine N-oxide)誘導体の開発・製造を、当社提携先であるインドのSapala Organics Pvt.Ltdにて行います。

Sapala Organics Pvt.Ltdについて詳細はこちらをご覧ください。

引用・文献名: 薬局 2011 Vol.62 No.12 インフルエンザ治療における新規治療薬・治療戦略ファビピラビル(T-705)
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