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核酸医薬 ~ 原料調達・開発・製造 ~

核酸医薬とは

  DNA や RNA といった遺伝情報をもつ核酸を医薬品として利用されるのが、核酸医薬品です。
従来の低分子医薬品や抗体医薬品では標的とすることが難しかった細胞内の分子に作用できるため、効果が高く副作用が少ないと期待されており、次世代医薬品として高い期待が寄せられています。 癌や遺伝性疾患に対する革新的医薬品としての発展が期待されています。

ホスホロアミダイト試薬

 DNA・RNA 合成用アミダイト試薬の製造・販売をさせていただいています。新規の合成も積極的に検討をさせていただきます。
  • 2-CYANOETHYL DIISOPROPYL CHLOROPHOSPHORAMIDITE MIN. 98.5% / CAS:89992-70-1
  • CYANOETHYL N,N,N',N'-TETRAISOPROPYLPHOSPHORDIAMIDITE MIN. 98% / CAS:102691-36-1

ヌクレオシド誘導体・修飾ヌクレオシド

  • LNA, ALNA モノマー (10 ㎏以上に対応可能)
  • LNA, ALNA アミダイト 10 ㎏以上に対応可能 (但し、1 ㎏/1 ロット)
  • BNA モノマー (10 ㎏以上に対応可能)
  • BNA アミダイト (1 ㎏まで対応可能)
  • 修飾ヌクレオシド三リン酸
  • C5-修飾ヌクレオシド
  • 2’又は 3’フルオロヌクレオシド
  • モルホリノヌクレオシド
  • L-ヌクレオシド
  • C-ヌクレオシド
  • 糖部位修飾ヌクレオシド
  • 塩基部位修飾ヌクレオシド
  • 糖・塩基部位修飾ヌクレオシド
  • 重水素標識ヌクレオシド
 *化合物例は裏面に記載させていただいております

オリゴ核酸合成

 秘密保持締結下、オリゴ核酸合成へ取り組んでおります。

核酸医薬 検討用試薬

商品名 構造式
1-(3-Hydroxy-5-hydroxymethyl-4-methoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
1-(3-Hydroxy-5-hydroxymethyl-4-methoxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
4-Amino-1-(3-hydroxy-5-hydroxymethyl-4-methoxy-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one
N-[1-(3-Hydroxy-5-hydroxymethyl-4-methoxy-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]
2-(6-Amino-purin-9-yl)-5-hydroxymethyl-4-methoxy-tetrahydro-furan-3-ol
N-[9-(3-Hydroxy-5-hydroxymethyl-4-methoxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide
1-(4-Fluoro-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
1-(4-Fluoro-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
4-Amino-1-(4-fluoro-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one
N-[1-(4-Fluoro-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide
2-(6-Amino-purin-9-yl)-4-fluoro-5-hydroxymethyl-tetrahydro-furan-3-ol
N-[9-(4-Fluoro-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide
4-Amino-1-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one
N-[1-(4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide
5-(6-Amino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-ol
N-[9-(4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide
[5-(6-Amino-purin-9-yl)-tetrahydro-furan-2-yl]-methanol
1-(5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
1-(3,4-Dihydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
1-(3,4-Dihydroxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
4-Amino-1-(3,4-dihydroxy-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one
N-[1-(3,4-Dihydroxy-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide
2-(6-Amino-purin-9-yl)-tetrahydro-furan-3,4-diol
N-[9-(3,4-Dihydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide
1-(3,4-Dihydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
1-(3,4-Dihydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
4-Amino-1-(3,4-dihydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one
N-[1-(3,4-Dihydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-
yl]-benzamide
2-(6-Amino-purin-9-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol
N-[9-(3,4-Dihydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide
3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene] -6-carboxylic acid
3',6'-dihydroxy-4,7,2',7'-tetrachloro-3-oxospiro[2-benzofuran-1,9'-xanthene]-6-carboxylic acid
3',6'-dihydroxy-4,7,2',4',5',7'-hexachloro-3-oxospiro[2-benzofuran-1,9'-xanthene]-6-carboxylic acid
3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid
3',6'-dihydroxy-4,7,2',7'-tetrachloro-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid
3,6-Dichloro-benzene-1,2,4-tricarboxylic acid
1-(2,5-Dichloro-3,6-dimethyl-phenyl)-ethanone
3,5-Dichloro-2,4-dihydroxy-benzoic acid methyl ester
3,5-Dichloro-2,4-dihydroxy-benzoic acid
4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-carbonitrile
採用情報

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