ピラジン・ｷﾉｷｻﾘﾝ化合物の開発・製造 ～ 医薬品原料・電子材料への応用 ～
当社では医薬品原料・電子材料への応用が期待されるピラジン・キノキサリン化合物の開発・受託製造を行っております。考えられる用途：
- エボラ出血熱治療薬で注目されるピラジン骨格
- 不斉合成原料
- 抗インフルエンザ薬：アビガン(一般名 ファビピラビル / Favipiravir) 等
- 抗結核薬
- 高脂血症治療薬
- 色素増感太陽電池素材
- 有機 EL 素子
- 有機半導体
- 電子感光体
新規化合物にもラボスケールから対応させていただきます。
製品例の紹介（主な製造先：インド）
| CAS No. | 品名 | 構造式 |
|---|---|---|
| 1076198-72-5 | 2-(1-Acetoxyethyl)-3-ethyl-5-methylpyrazine |  |
| 160252-31-3 | 5-Acetyl-2-chloropyrazine |
|
| 21943-12-4 | 2-Amino-3-bromopyrazine |
|
| 59489-71-3 | 2-Amino-5-bromopyrazine |
|
| 887352-34-3 | 2-Amino-3-bromopyrazine-5-carboxylic acid |
|
| 486424-37-7 | 2-Amino-5-bromopyrazine-3-carboxylic acid |
|
| 6966-01-4 | 2-Amino-5-bromopyrazine-3-carboxylic acid methyl ester |
|
| 6663-73-6, 6863-73-6 |
2-Amino-3-chloropyrazine |
|
| 33332-29-5 | 2-Amino-5-chloropyrazine |
|
| 33332-28-4 | 2-Amino-6-chloropyrazine |
|
| 43029-19-2 | 2-Amino-3-hydroxypyrazine |
|
| 771581-15-8 | 2-Aminomethyl-3-chloropyrazine |
|
| 5049-61-6 | 2-Aminopyrazine |
|
| 5424-01-1 | 3-Amino-2-pyrazinecarboxylic acid |
|
| 40155-43-9 | 5-Amino-2-pyrazinecarboxylic acid |
|
| 61442-38-4 | 6-Amino-2-pyrazinecarboxylic acid |
|
| 40155-43-9 | 5-Aminopyrazine-2-carboxylic acid |
|
| 13924-94-2 | 2-Aminopyrazine-5-carboxylic acid methyl ester |
|
| 16298-03-6 | 3-Amino-2-pyrazinecarboxylic acid methyl ester |
|
| 1076198-91-8 | 1-Benzyl 4-[6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl]piperazine-1,4-dicarboxylate |
|
| 96681-85-5 | 3,6-Bis(2-hydroxyethyl)-2-pyrazinepropanoic acid |
|
| 875781-43-4 | 2-Bromo-5H-pyrrolo[3,2-b]pyrazine |
|
| 259793-88-9 | 6-Bromo-3-hydroxypyrazine-2-carboxamide |
|
| 914452-71-4 | 2-Bromo-6-methylpyrazine |
|
| 1416740-16-3 | 2-Bromo-7-nitro-5H-pyrrolo[3,2-b]pyrazine |
|
| 59489-71-3 | 5-Bromopyrazin-2-amine |
|
| 56423-63-3 | 2-Bromopyrazine |
|
| 89123-58-0 | 5-Bromopyrazine-2,3-diamine |
|
| 132426-19-8 | 2-Bromo-1-(2-pyrazinyl) ethanone |
|
| 173256-61-6 | 2-Chloro-6-(2'-deoxy-b-D-ribofuranosyl)-3,5-diaminopyrazine |
|
| 33332-25-1 | 5-Chloro-2-methoxycarbonyl pyrazine |
|
| 40155-28-0 | 2-Chloro-3-methoxy pyrazine |
|
| 1122549-47-6 | 3-(Chloromethyl)-N-(5-chloro-2-pyridinyl)-2-pyrazinecarboxamide |
|
| 508169-18-4 | 7-Chloromethyloxy-carbonyloxy-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one |
|
| 36070-80-1 | 5-Chloropyrazine-2-carboxylic acid |
|
| 23688-89-3 | 6-Chloropyrazine-2-carboxylic acid |
|
| 27825-21-4 | 3-Chloro-2-pyrazinecarboxylic acid methyl ester |
|
| 19847-12-2 | 2-Cyanopyrazine |
|
| 402958-96-7 | (2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valine |
|
| 2015-16-9 | Des(5-methylpyrazinecarbonyl) glipizide | |
| 1458-01-1 | 3,5-Diamino-6-chloropyrazine-2-carboxylic acid methyl ester |
|
| 944709-42-6 | 6,8-Dibromo-[1,2,4]triazolo[1,5-a]pyrazine |
|
| 957230-70-5 | 2,5-Dibromo-3-aminopyrazine |
|
| 1082843-70-6 | 3,5-Dibromo-2-chloropyrazine |
|
| 1198475-31-8 | 6,8-Dibromo-2-methyl-[1,2,4]triazolo[1,5-a]pyrazine |
|
| N/A | 2,5-Dibromo-3-methylcarboxylatepyrazine | |
| 957230-70-5 | 3,6-Dibromopyrazin-2-amine |
|
| 24241-18-7 | 3,5-Dibromopyrazin-2-amine |
|
| 23229-26-7 | 2,5-Dibromopyrazine |
|
| 23229-25-6 | 2,6-Dibromopyrazine |
|
| N/A | 2,5-Dibromopyrazine-3-carboxylic acid | |
| 4858-85-9 | 2,3-Dichloropyrazine |
|
| 4774-14-5 | 2,6-Dichloropyrazine |
|
| 313339-92-3 | 3,5-Dichloropyrazine-2-carbonitrile |
|
| 312736-49-5 | 3,5-Dichloropyrazine-2-carboxamide |
|
| 52197-23-6 | 2,3-Dicyano-5,6-diphenylpyrazine |
|
| 134870-62-5 | (S)-3,6-Diethoxy-2,5-dihydro-2-isopropylpyrazine |
|
| 1076200-01-5 | 2,3-Diethyl-5-methylpyrazine-N4-oxide |
|
| 1076200-00-4 | 2,3-Diethyl-5-methylpyrazine-N1-oxide |
|
| 312905-15-0 | 1,1-Difluorocyclopropane-1-dibenzosuberyl pyrazinium bromide |
|
| 1174321-06-2 | 5-Difluoromethylpyrazine-2-carboxylic acid |
|
| 356783-29-4 | 3,6-Difluoropyrazine-2-carboxamide |
|
| 110117-71-0 | (R)-2, 5-Dihydro-3,6-diethoxy-2-isopropylpyrazine |
|
| 656241-17-7 | (2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine |
|
| 109838-85-9 | (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine |
|
| 78342-42-4 | (S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine |
|
| 1093418-77-9 | 2,5-Diiodopyrazine |
|
| 13925-07-0 | 3,5-Dimethyl-2-ethylpyrazine |
|
| 108-50-9 | 2,6-Dimethyl pyrazine |
|
| 52197-22-5 | 2,3-Diphenyl-5,8-diaminopyrazino[2,3-d]pyridazine |
|
| 79790-37-7 | Dipyrazino[2,3-f:2',3'-h]quinoxaline |
|
| 157615-33-3 | 2-Ethenyl-3,5-dimethylpyrazine | |
| 181589-32-2 | 2-Ethenyl-3-ethyl-5-methylpyrazine |
|
| N/A | Ethyl-1-[2-(2-oxo-2-pyrazin-2-ylethylidene)tetrahydropyrimidin-1-yl]ethanoate | |
| 54013-06-8 | Ethyl 5-aminopyrazine-2-carboxylate |
|
|
27043-05-6, 55031-15-7 |
2-Ethyl-3,5-dimethylpyrazine |
|
| 86917-74-0 | 3-Ethyl-2,5-pyrazinediethanol |
|
| N/A | Hexyl-3-[5-(2-hexyloxycarbonylethyl)pyrazin-2-yl]propionate | |
| N/A | 2-Hydroxy-3,3-dimethyl-2,3-dihydropyrazine> -1,4-dioxide |
|
| 34604-60-9 | 5-Hydroxypyrazine-2-carboxylic acid |
|
| 77112-53-9 | Imidazo[1,2-a]pyrazine-2-carboxylic acid |
|
| 38521-06-1 | 2-Mercaptopyrazine |
|
| 40155-42-8 | 5-Methoxypyrazine-2-carboxylic acid |
|
| 77479-01-7 | Methyl-3-[5-(2-methoxycarbonylethyl)pyrazin-2-yl]propionate |
|
| 1076198-49-6 | Methyl 2-amino-3-bromopyrazine-5-carboxylate |
|
| 5521-55-1 | 5-Methyl-2-pyrazinecarboxylic acid |
|
| 51037-30-0 | 5-Methylpyrazine-2-carboxylic acid 4-oxide |
|
| 54709-94-3 | 5-Methylpyrazinone |
|
| 1122549-43-2 | N-(5-Chloro-2-pyridinyl)-3-(hydroxymethyl)-2-pyrazinecarboxamide |
|
| 13554-93-3 | N-Des(5-methylpyrazinecarbonyl)-N-ethylcarboxyl glipizide | |
| 114457-94-2 | N-Pyrazinylcarbonyl-L-phenylalanine |
|
| 73058-37-4 | N-Pyrazinylcarbonyl-L-phenylalanine methyl ester |
|
| 24177-07-9 | (2R,5S,10aS,10bS)-Octahydro-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxo-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine-2-carboxylic acid |
|
| 1159825-34-9 | Octahydro-2H-pyrazino[1,2-a]pyrazine-2-carboxylic acid tert-butyl ester |
|
| 6303-75-9 | Pentylpyrazine |
|
| 205393-22-2 | (1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate |
|
| 98-96-4 | Pyrazinamide |
|
| 768-05-8 | Pyrazine-2-carbohydrazide |
|
| 98-97-5 | Pyrazine-2-carboxylic acid |
|
| 874-54-4 | 2-Pyrazinecarboxylic acid 4-oxide |
|
| 89-01-0 | 2,3-Pyrazine dicarboxylic acid |
|
| 4744-51-8 | 2,5-Pyrazinediethanol |
|
| 2423-84-9 | Pyrazine 1,4-dioxide |
|
| 24168-70-5 | 2-sec-Butyl-3-methoxypyrazine |
|
| 51440-69-8 | 5-(tert-Butyl)pyrazine-2,3-dicarbonitrile |
|
| 230615-70-0 | 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine |
|
| 88571-73-7 | 2,2,5,5-Tetramethyl-2,5-dihydropyrazine-1,4-dioxide |
|
| 1124-11-4 | 2,3,5,6-Tetra-methyl-pyrazine |
|
開発製品例の紹介
A. Alkylpyrazine and Alkylpyrazine N-oxides
- 1）2,5-dialkylpyrazine
- 2）2,5-alkylpyrazine mono-N-oxides
- 3）2,5-alkylpyrazine di-N-oxides
B. Arylpyrazines
- 1） monoarylpyrazines
- 2） 2,3-diarylpyrazines
- 3） 2,3-diarylpyrazine N-oxides
- 4） 2,5-diarylpyrazines
- 5） 2,6-diarylpyrazines
C. Condensation pyrazines
- C. Condensation pyrazines
その他の誘導体への対応
当社では、ピラジン(Pyrazine)及びピラジン N-オキシド(Pyrazine N-oxide)誘導体の開発・製造を、当社提携先であるインドのSapala Organics Pvt．Ltdにて行います。Sapala Organics Pvt．Ltdについて詳細はこちらをご覧ください。
引用・文献名: 薬局 2011 Vol.62 No.12 インフルエンザ治療における新規治療薬・治療戦略ファビピラビル(T-705)
